Abstract
Benign pulmonary lymphoid disorders include a variety of rare lymphoid abnormalities
characterized by a polyclonal lymphoid infiltrate with differing histopathologic patterns
and clinicoradiologic features that may overlap. Histological examination is essential
to reach a correct diagnosis and to exclude alternative causes, although this task
can at times prove difficult. Further studies and clinical trials are needed to provide
additional insights on pathogenesis and to guide the therapeutic management of these
disorders. The purpose of this article is to review the histopathological, epidemiological,
and clinicoradiologic features of several benign pulmonary lymphoid disorders, including
lymphoid interstitial pneumonia, follicular bronchiolitis, nodular lymphoid hyperplasia
(pulmonary pseudolymphoma), inflammatory pseudotumor, immunoglobulin G4-related disease,
Castleman disease, posttransplantation lymphoproliferative disease, and drug-induced
lymphoid disorders.
Keywords
lymphoid interstitial pneumonia - pulmonary lymphoid disorders - pseudolymphoma -
Castleman disease